First Single-Cell 3D Genome Atlas of Human Tonsil Published in Science
anshulkundaje · x · 2026-07-25
A new study published in Science presents the first single-cell 3D genome atlas of the human tonsil and B cell immunity. This also marks the first image-based 3D genomics dataset for any human tissue.
The research identifies a novel chromatin "curl" structure and uncovers a new function for cohesin loop extrusion. Leveraging AI and genomic analysis, the paper explores the mechanisms of somatic hypermutation (SHM) during antibody affinity maturation and how these mutations contribute to chromosomal translocations driving B cell oncogenesis.
More from Research
- Nature paper images cellular activity across all organs, revealing body-wide circuits — arjunrajlab · 2026-09-11
- Skyfall GS Uses Flux to Refine Gaussian Splatting, Accepted at ECCV 2026 — ducha_aiki · 2026-09-11
- Could 10k agents discover learning methods beyond backprop, or just tweak existing ones? — SeunghyunSEO7 · 2026-09-11
- Apodex Launches TRACES, First Benchmark for Evaluating 'Discoverative AI' on Real-World Problems — Faheem_uh · 2026-09-11
- TRACES grades the process, not the answer: six-dimension eval for open-ended AI science — Faheem_uh · 2026-09-11
- Apodex launches TRACES, a benchmark grading AI on open-ended discovery instead of known answers — Faheem_uh · 2026-09-11