First Single-Cell 3D Genome Atlas of Human Tonsil Published in Science
anshulkundaje · x · 2026-07-25
A new study published in Science presents the first single-cell 3D genome atlas of the human tonsil and B cell immunity. This also marks the first image-based 3D genomics dataset for any human tissue.
The research identifies a novel chromatin "curl" structure and uncovers a new function for cohesin loop extrusion. Leveraging AI and genomic analysis, the paper explores the mechanisms of somatic hypermutation (SHM) during antibody affinity maturation and how these mutations contribute to chromosomal translocations driving B cell oncogenesis.
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