Science study maps single-cell 3D genome rewiring in Alzheimer’s with a transformer model
jmuiuc · x · 2026-07-24
A Science paper on single-cell 3D genome reorganization in Alzheimer’s disease combines gene expression, 3D genome architecture, chromatin accessibility, and spatial transcriptomics in individual human brain cells.
Key findings:
- The team measured these modalities jointly with GAGE-seq.
- They observed increased compartment mingling and distance-dependent rewiring of gene-regulatory contacts in AD.
- They introduced Hicformer, a transformer model that fuses DNA sequence with 3D genome features to predict cell-type-specific gene expression and prioritize candidate regulatory elements.
The quote also highlights that earlier methods such as Higashi, Fast-Higashi, scGHOST, and Hi-C chromVAR were key components of the analysis pipeline.
Related event: Science Study Reveals 3D Genome Restructuring in Alzheimer's(4 posts)→
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