enFoldX uses noisy AlphaFold3 ensembles to predict T cell specificity
quaidmorris · x · 2026-07-22
enFoldX targets a long-standing TCR specificity problem
The post frames the problem as predicting which T cells recognize which peptides. Sequence-based models often fail to generalize to new peptides or new TCRs, while AlphaFold3 may still generate plausible-looking structures even for non-cognate pairs.
The proposed solution, enFoldX, uses the full noisy AF3 ensemble instead of a single structure to predict TCR:pMHC binding.
Related event: enFoldX Turns AlphaFold3 Noise into TCR Recognition Signals(11 posts)→
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