Structural ensembles, not single predictions, drive robust TCR:pMHC generalization
quaidmorris · x · 2026-07-22
- The reply highlights a key takeaway from the study: structural ensembles, not a single predicted structure, carry the biophysical signal needed for robust generalization in TCR:pMHC prediction.
- The authors say the same framework should extend beyond AF3 to Boltz, RoseTTAFold, OpenFold, and related models.
- The post also names the multi-author team behind the work, indicating this is a collaborative research result rather than a casual opinion.
Related event: enFoldX Turns AlphaFold3 Noise into TCR Recognition Signals(11 posts)→
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