TRU-FACT aligns brain activity imaging with spatial transcriptomics at scale
fatihdin4en · x · 2026-07-21
TRU-FACT is a graph-based method that aligns cells across in vivo neural activity imaging and spatial transcriptomics at scale.
The post says the work is a finalist in the 2026 BRAIN Initiative Photo & Video Contest and highlights its use in mice with conventional, mesoscope, GRIN-lens, or miniature two-photon imaging paired with HCR-FISH or MERFISH. The goal is a scalable pipeline for image alignment and cell registration in multimodal neuroscience.
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