DeCAF Accelerates Protein-Ligand Co-folding

FrankNoeBerlin · x · 2026-07-10

DeCAF is a few-step model for protein-ligand co-folding utilizing all-atom flow maps and a novel flow-map framework. The author claims it is up to 5x faster than the SOTA Pearl and 20x faster than Boltz 1x while maintaining sample quality.

Related event: DeCAF Framework Speeds Up Protein-Ligand Co-Folding Nearly 5x(2 posts)→

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