De novo designed cysteine proteases published in Nature

David Baker's lab published a Nature paper on de novo designed cysteine proteases that can cleave target proteins, with activity validated in mammalian cells. The work, built on RFdiffusion-style methods, reported a 19% design success rate and open-sourced its code.

2026-10-19 ~ 2026-10-20 · 2 related posts

• Baker lab designs de novo cysteine proteases that cleave peptide bonds, published in Nature — DaveJuergens · 2026-10-19
• De novo cysteine proteases published in Nature with 19% design success rate — JosephJacks_ · 2026-10-20