578 Variants Show Protein Domains Must Be Designed in Context

A paper by Bülbül et al. shows through 578 variants designed with ESM3, ProteinMPNN and EvoDiff that protein domains cannot be designed in isolation—their function depends on neighboring domains. The work was highlighted in an AI for Science newsletter.

2026-09-25 ~ 2026-09-25 · 2 related posts

• Protein design must account for neighbors: 578 variants show similarity predicts function poorly — bravo_abad · 2026-09-25
• Designing protein domains with ESM3: function depends on the neighborhood, not isolation — bravo_abad · 2026-09-25