Genomic Language Model Designs Non-Natural Biosynthetic Assembly Lines

Teams from UC Berkeley, UCSF and LBL posted a bioRxiv paper using the genomic language model gLM2 to generatively design new-to-nature polyketide synthase assembly lines that produce molecules not found in nature, tackling complex cross-domain interactions via training on massive evolutionary data.

2026-09-18 ~ 2026-09-19 · 3 related posts

• Genomic language model gLM2 controllably generates new biosynthetic domain architectures — BrianHie · 2026-09-18
• Genomic language model designs new-to-nature polyketide synthases for non-natural products — KevinKaichuang · 2026-09-19

1 near-duplicate retellings: KevinKaichuang