GPN-Star hits Nature, beating 40B Evo 2 with 200M parameters
UC Berkeley's GPN-Star, published in Nature, injects phylogenetic priors into a genomic language model; with just 200M parameters it beats the 40B Evo 2 on variant-effect prediction, reaching SOTA.
2026-09-09 ~ 2026-09-10 · 3 related posts
- GPN-Star: evolution-aware genome model hits SOTA, published in Nature — EricTopol · 2026-09-09
- GPN-Star: phylogeny-aware genomic language model hits SOTA on variant effect prediction — pastramimachine · 2026-09-10
- 200M-parameter GPN-Star beats 40B Evo 2 by encoding evolutionary priors — bravo_abad · 2026-09-10