Microsoft Research: Dropping Singleton Proteins in PLM Training May Be Wrong
A Microsoft Research and Brown University preprint argues that the common practice of discarding singleton metagenomic proteins when training protein language models hurts performance and loses functional diversity.
2026-08-18 ~ 2026-08-18 · 3 related posts
- Microsoft Research: discarding singleton proteins in PLM training is likely wrong — KevinKaichuang · 2026-08-18
- Discarding Singletons May Harm Protein Language Model Training — KevinKaichuang · 2026-08-18
- Don't discard singleton proteins: study challenges standard protein LM training data filtering — KevinKaichuang · 2026-08-18